Mega Testing Diagnostic Platforms

https://twitter.com/BillGates/status/1356374923078369281

Watch your red blood cells citizen good ole Uncle Bill is out to perform mega tests on them and rapidly roll out untested mRNA vaccines and monoclonal antibodies on the world.

To start, there has never been a successfully developed and deployed coronavirus vaccine to humans. The vaccines developed for SARS-CoV-2 are novel vaccines. Nobody truly knows if these vaccines are effective or why.

Why these vaccines seem so effective while previous attempts against other pathogens haven’t appeared as promising remains an open question. One simple reason, according to Liu, might be the sheer volume of resources that were poured into developing them. Liu also hypothesizes that one explanation for the high levels of efficacy is that the vaccines might be triggering a nonspecific inflammatory response to the mRNA that could be heightening its specific immune response, given that the modified nucleoside technique reduced inflammation but hasn’t eliminated it completely. On the flip side, she adds, this may also explain the intense reactions such as aches and fevers reported in some recipients of the mRNA SARS-CoV-2 vaccines. (Others have suggested that the lipid nanoparticle is responsible for these severe, but transient, side effects reported in some trial participants.)

Ultimately, it’s too early to say why these vaccines so far appear to work so well. “These do remain interim results. They do remain unpublished. And we still need to see the extensive safety databases associated with these products,” Jackson says. There are also issues to sort out, such as concerns about needing to store the vaccines in freezers—especially in the case of the Pfizer/BioNTech vaccine, which needs to be kept at –70 °C.

The Scientist

mRNA vaccines have never been approved for humans before. The same approach used in the SARS-CoV-2 vaccine also failed when Moderna used the technique for another illness.

In order to protect mRNA molecules from the body’s natural defenses, drug developers must wrap them in a protective casing. For Moderna, that meant putting its Crigler-Najjar therapy in nanoparticles made of lipids. And for its chemists, those nanoparticles created a daunting challenge: Dose too little, and you don’t get enough enzyme to affect the disease; dose too much, and the drug is too toxic for patients.

From the start, Moderna’s scientists knew that using mRNA to spur protein production would be a tough task, so they scoured the medical literature for diseases that might be treated with just small amounts of additional protein.

“And that list of diseases is very, very short,” said the former employee who described Bancel as needing a Hail Mary.

Crigler-Najjar was the lowest-hanging fruit.

Yet Moderna could not make its therapy work, former employees and collaborators said. The safe dose was too weak, and repeat injections of a dose strong enough to be effective had troubling effects on the liver in animal studies.

statnews.com

Of course this doesn’t mean technology can’t be improved and the problem solved. I would just feel better about it if it went through animal testing before rolled out into humans. It’s already been reported that people that are old, frail, or have severe allergies maybe should not take the Pfizer or Moderna vaccines.

Bill Gates touts that mRNA vaccines are easier to store. Nothing is further from the truth. It’s been widely reported that the Pfizer vaccine requires temperatures so cold as to require special equipment while the Moderna vaccine supposedly can be held at temperatures of a home freezer. Both require special handling however.

Bill calls for a Global Alert System in order rally the troops to tackle the next pandemic. I worry about guys like him promoting programs that require a functioning one world government. You can’t just roll things like this out. You need the permission of nations all over the world. Many of which don’t have the rights of the citizens protected. The U.S. Constitution, while eroding in power, still protects the rights of the individual from an intrusive government. What will citizens of Africa do when this one world government wants to use them as the world’s guinea pigs?


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